Journal article
Repeated local emergence of carbapenem-resistant Acinetobacter baumannii in a single hospital ward
MB Schultz, DP Thanh, NTD Hoan, RR Wick, DJ Ingle, J Hawkey, DJ Edwards, JJ Kenyon, NPH Lan, JI Campbell, G Thwaites, NTK Nhu, RM Hall, A Fournier-Level, S Baker, KE Holt
Microbial Genomics | Published : 2016
Abstract
We recently reported a dramatic increase in the prevalence of carbapenem-resistant Acinetobacter baumannii infections in the intensive care unit (ICU) of a Vietnamese hospital. This upsurge was associated with a specific oxa23-positive clone that was identified by multilocus VNTR analysis. Here, we used whole-genome sequence analysis to dissect the emergence of carbapenem-resistant A. baumannii causing ventilator-associated pneumonia (VAP) in the ICU during 2009–2012. To provide historical context and distinguish microevolution from strain introduction, we compared these genomes with those of A. baumannii asymptomatic carriage and VAP isolates from this same ICU collected during 2003–2007. W..
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Awarded by Wellcome Trust
Funding Acknowledgements
This work was funded by the NHMRC of Australia (Grant #1043830 to KEH and RMH, #1026189 to RMH, and Fellowship #1061409 to KEH), the Victorian Life Sciences Computation Initiative (VLSCI) (Grant #VR0082) and the Wellcome Trust of the United Kingdom. SB is a Sir Henry Dale Fellow, jointly funded by the Wellcome Trust and the Royal Society (100087/Z/12/Z). We thank the editors and two anonymous reviewers whose suggestions helped to improve this manuscript.